Multi‑target inhibition by four tandem shRNAs embedded in homo‑ or hetero‑miRNA backbones
نویسندگان
چکیده
منابع مشابه
Homo floresiensis: microcephalic, pygmoid, Australopithecus, or Homo?
The remarkable partial adult skeleton (LB1) excavated from Liang Bua cave on the island of Flores, Indonesia, has been attributed to a new species, Homo floresiensis, based upon a unique mosaic of primitive and derived features compared to any other hominin. The announcement precipitated widespread interest, and attention quickly focused on its possible affinities. LB1 is a small-bodied hominin...
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Ab? Sahl W?jan (B?zhan) ibn Rustam al-K?h? the 10th century mathematician and astronomer was from Tabarist?n (present M?zandar?n) province of Iran. Apart from his rich legacy kept in several manuscripts and studied, edited and translated widely, we know that some of his works have been lost. In this article, K?h?’s lost mathematical works are traced through references and quotations in the work...
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BACKGROUND RhoA and RhoC are deregulated by over expression in many human tumors, including colorectal cancer. Some reports show that they play a pivotal role in the carcinogenesis, tumor development and infiltration metastasis. In this study, for the first time we constructed recombinant adenovirus to investigate the inhibitory effects of RhoA and RhoC shRNAs in tandem expression on the cell p...
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RNA interference is triggered by small hairpin precursors that are processed by the endonuclease dicer to yield active species such as siRNAs and miRNAs. To regulate the RNAi-mediated suppression of gene expression, we imagined a strategy that relies on the sequence-specific inhibition of shRNA precursor processing by immediate RNA-small molecule interactions. Here, we present a first step in t...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.7854